Dr. Sima Tarzami, Ph.D.
Office Location: Seeley G. Mudd Building Room 329
Office Telephone: 202-806-5269
Laboratory Location: Adams Building Room 4408
B.A., Hofstra University, New York (1992)
M.S., Hofstra University, New York (1995)
Ph.D., Albert Einstein College of Medicine, New York (2002)
Postdoctoral Fellow, Eli Lilly Pharmaceutical Company (2004-2006)
Postdoctoral Fellow, Albert Einstein College of Medicine (2006-2008)
- Cell and Molecular Biology
- Cardiac Physiology and Pharmacology
My laboratory studies the role of chemokines on cardiac myocyte biology. We focus on cardiac physiology in both in vitro and in vivo models of heart failure targeting specific signaling pathways. We have demonstrated that chemokines, once thought to act only on inflammatory cells, can elicit biological responses from cardiac myocytes. This line of research is unique in bridging the areas of immunology (i.e. chemokines) and cardiovascular biology. Our focus is particularly on the CXCR4-CXCL12 regulation and signaling pathways in cardiac myocytes. The CXCR4-CXCL12 regulation and signaling pathways have been extensively studied in developmental processes, stem cell biology and in metastatic disease, focusing primarily on cells with a migratory phenotype. There is little known about CXCR4 signaling in cardiac myocytes. Our studies suggest that under conditions of stress, the paracrine and/or autocrine activation of CXCR4 by its ligand may trigger intracellular signaling pathways which may exacerbate contractile dysfunction. We have demonstrated a clear interaction between CXCR4 and Beta-2 adrenergic receptor and that CXCR4 activation can interfere with Beta adrenergic receptor downstream signaling. In the light of Beta adrenergic importance in progression of heart failure, we have set to examine the mechanistic role of CXCL12-CXCR4 in the pathophysiology of heart disease.
Chemokines and Heart disease: Adaptive or Maladaptive
Beta-2 adrenergic-mediated cardiac dysfunction
L type Ca channels activity and heart function
Cardiac hypertrophy and failure
Grants and Funding Awards
National Heart, Lung, and Blood Institute (NHLBI) (2010-2013)
American Heart Association (2010-2013)
American Heart Association (2007-2010)
1) Malik Bisserier, Javier Milara, Sarah Gubara, Carly Jones, Carlos Bueno-Beti, Elena Chepurko, Erik Kohlbrenner, Michael G. Katz, Anthony Fargnoli, Sima Tarzami, Julio Cortijo, Jane Leopold, Roger J. Hajjar, Yassine Sassi, Lahouaria Hadri. Targeted Gene Therapy using AAV1.Serca2a reverses Pulmonary Fibrosis By Blocking The STAT3/FOXM1 Pathway And Promoting The SNON/SKI Axis. Mol Ther J. 2020 Feb 5;28(2):394-410.
2) Thomas J LaRocca, Perry Altman, Andrew A Jarrah, Ron E. Gordon, Edward Wang, Lahouaria Hadri, Mark W. Burke, Georges E. Haddad, Roger J. Hajjar and Sima T. Tarzami. CXCR4 cardiac specific knockout mice develops a progressive cardiomyopathy. Int J Mol Sci. 2019 May 8;20(9).
3) Adam Abad, Ahmed Peeran, Janay I. Little, Georges E. Haddad, Sima T. Tarzami. Alcohol-Mediated Organ Damages: Heart and Brain. Review. Frontier in Pharmacology 2018 Feb 13;9:81. doi: 10.3389/fphar.2018.00081.
4) Andrew A. Jarrah, Martina Schwarskopf, Edward R. Wang, Thomas J LaRocca, Ashwani Dhume, Shihong Zhang, Lahouria Hadri, Roger J. Hajjar, Alison D. Schecter and Sima T. Tarzami. SDF-1 induces TNF-mediated apoptosis in cardiac myocytes. Apoptosis. 2018 Jan;23(1):79-91.
5) Delaine K. Ceholski, Irene C. Tumbull, Andrew A. Jarrah, Changwon Kho, Ahyoung Lee, Lahouaria Hadri, Kevin D. Costa, Roger J. Hajjar, and Sima T. Tarzami. A unique network involving CXCR4 and CXCR7 coordinates cardiac lineage specification and mobilization of induced pluripotent stem cells. Stem Cell Res. 2017 Aug;23:77-86.
6) Jarrah AA, Tarzami ST. The duality of chemokines in heart failure. Review. Expert Rev Clin Immunol. 2015 Apr;11(4):523-36.
7) Wang ER, Jarrah AA, LaRocca TJ, Benard L, Chen J, Tarzami ST. Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration. Gene Ther. 2014 May;21(5):496-506.
8) Larissa Lipskaia, Regis BOBE, Jiqiu Chen, Irene C. Turnbull, jose-javier lopez-barba, Elise Merlet, Dongtak Jeong, Ioannis Karakikes, Alexandra Ross, Lifan Liang, Nathalie Mougenot, Fabrice Atassi, Anne-Marie Lompre, Sima T Tarzami, Jason Kovacic, Evangelia Kranias, Roger Hajjar, and Lahouaria Hadri. Synergistic role of Protein Phosphatase Inhibitor 1 and SERCA2a in the acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells. Circulation. 2014 Feb 18;129(7):773-85.
9) LaRocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST. CXCR4 gene transfer prevents pressure overload induced heart failure. J Mol Cell Cardiol. 2012 Aug;53(2):223-32.
10) LaRocca T, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST. B2 adrenergic receptor in the heart is modulated by interactions with CXCR4 chemokine receptor. J Cardiovasc Pharmacol. 2010 Nov;56(5):548-59.
11) Chen J, Chemaly E, Liang L, Kho C, Lee A, Park J, Altman P, Schecter AD, Hajjar RJ, Tarzami ST. Effects of CXCR4 gene transfer on cardiac function following ischemia-reperfusion. Am J Pathol. 2010 Apr;176(4):1705-15.