Prosper N’Gouemo

Prosper N’Gouemo, PhD

Associate Professor

Contact Information
Office: Seely G. Mudd Building, Room 333
Office telephone: 202-806-9708
Laboratory: Numa P. Adams Building, Room 4402





PhD (Doctorat d’Etat), Physiology, University of Montpellier I, France,1991


  • Neurophysiology
  • Neuroscience

Research: Ion channels, Seizures, and Epilepsy

  • Neurobiology of inherited epilepsy
  • Basic mechanisms of alcohol withdrawal-induced seizures
  • Neurobiology of prenatal alcohol exposure-related seizures

Grant Funding (Active)

R21 AA027171
Pediatric seizures: role of IP3R Ca2+ release channels
Role: PI
R01 AA027660
Na2+/Ca2+ exchanger remodeling in alcohol withdrawal seizures
Role: PI

Selected Peer-Reviewed Publications

Cho SJ, Newton J, Kandhai P, Lovinger DM, N’Gouemo P (2020). Prenatal alcohol exposure in the second trimester-equivalent preferentially increases seizure susceptibility in male developing rats. Alcohol 2020 Feb 28;85:153-164. doi: 10.1016/j.alcohol.2020.01.005. PMID:32114257.

Wicker E, Beck VC, Soper C, Kulick-Soper CV, Hyder SK, Campos-Rodriguez C, Khan T, NGouemo P, Forcelli PA (2019). Descending projections from the substantia nigra pars reticulata differentially control seizures. Proceedings of the National Academy of Science of the United States of America. 2019 Dec 16. pii: 201908176. doi: 10.1073/pnas.1908176117. PMID: 31843937.

Aguilar BL, Malkova L, N’Gouemo P, Forcelli PA (2018). Neuropsychiatric comorbidities in the genetically epilepsy-prone rats. Frontiers in Neurology “Experimental Models of Epilepsy and related comorbidities”.  Frontiers in Neurology, 2018 June 27;9:476. PMID: 29500720.

Lee Y, Rodriguez O, Albanese C, Santos V, Cortes de Oliveira J, Ferreira A, Fernandes A, Garcia-Cairsco N, N’Gouemo P, Forcelli PA (2018). A Voxel-based morphometry and diffusion tensor imaging comparison of two audiogenic rat strains: the Genetically Epilepsy Prone Rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). Neurobiology of Disease 2018 Mar;111:80-90.doi: 10.1016/j.nbd.2017.12.014. PMID:

Cho SJ, Vaca MA, Miranda CJ, N’Gouemo P (2018). Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy-prone rat. CNS Neuroscience & Therapeutics 2018 Jan;24(1):18-28, 2018. doi: 10.1111/cns.12770. PMID:29105300.

Cho SJ, Lovinger DM, N’Gouemo P (2017). Prenatal alcohol exposure enhances the susceptibility to NMDA-induced generalized tonic-clonic seizures in developing rats. CNS Neuroscience & Therapeutics 23(10):808-817. doi: 10.1111/cns.12756. PMID:28884976.

Akinfiresoye LR, Miranda C, Lovinger DM, N’Gouemo P (2016). Alcohol withdrawal increases protein kinase A activity in the rat inferior colliculus. Alcohol Clinical and Experimental Research 2016 Nov;40(11):2359-2367. doi: 10.1111/acer.13223. PMID:27716957.

Suman S, Kumar S, N’Gouemo P, Datta K (2016). Increased DNA double strand break was associated with downregulation of repair and upregulation of apoptotic factors in rat hippocampus after alcohol exposure. Alcohol 2016 Aug;54:45-50. doi: 10.1016/j.alcohol.2016.06.003. PubMed PMID:27565756.

Soper C, Wicker E, Kulick CV, N’Gouemo P, Forcelli PA (2016). Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks. Neurobiology of Disease 2016 Mar;87:102-15. doi: 10.1016/j.nbd.2015.12.012. PMID:26721319.

N’Gouemo P (2015). Altered voltage-gated calcium channels in rat inferior colliculus neurons contribute to alcohol withdrawal seizures. European Neuropsychopharmacology 2015 Aug 25(8):1342-1352. doi: 10.1016/j.euroneuro.2015.04.008. PMID:25914156.

N’Gouemo P, Morad M (2014). Alcohol withdrawal is associated with a downregulation of large-conductance Ca2+-activated K+ channels. Psychopharmacology (Berl) 2014 May;231(9):2009-2018. doi: 10.1007/s00213-013-3346-8. PMID:24241791.

N’Gouemo P (2013). Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures. Brain Research Bulletin 2013 Jan 90:52-7. doi: 10.1016/j.brainresbull.2012.09.007. PMID:22995283.