Prosper N’Gouemo, PhD
Laboratory: Numa P. Adams Building, Room 4402
PhD (Doctorat d’Etat), Physiology, University of Montpellier I, France,1991
Research: Ion channels, Seizures, and Epilepsy
- Neurobiology of inherited epilepsy
- Basic mechanisms of alcohol withdrawal-induced seizures
- Neurobiology of prenatal alcohol exposure-related seizures
Our long-term goal is to understand how controlling voltage-gated calcium channels and related calcium signaling can be used to prevent and/or treat inherited seizures, acquired epileptogenesis, alcohol withdrawal seizures, and prenatal alcohol exposure-related seizures. We also plan to identity genes that cause inherited seizure susceptibility in the genetically epilepsy-prone rats. To achieve these goals, we use models of seizures and epilepsy combined with electrophysiology, pharmacology, optogenetics, molecular genetics, and behavioral tests.
Grant Funding (Active)
Selected Peer-Reviewed Publications
Newton J, Akinfiresoye LR, N’Gouemo P (2021). Inhibition of the sodium calcium exchanger suppresses alcohol withdrawal-induced seizure susceptibility. Brain Sciences 2021 Feb 23;11(2)279.doi: 10.3390/brainsci11020279. PMID: 33672412
Santos VR, Hammack R, Wicker E, N’Gouemo P, Forcelli PA (2020). Divergent effects of systemic and intracollicular CB receptor activation against forebrain- and hindbrain-evoked seizures in rats. Frontiers in Behavioral Neuroscience 2020 Nov 17;14:595315. Doi: 10.3389/fnbeh.2020.595315.eCollection 2020. PMID: 33328922
Cho SJ, Newton J, Kandhai P, Lovinger DM, N’Gouemo P (2020). Prenatal alcohol exposure in the second trimester-equivalent preferentially increases seizure susceptibility in male developing rats. Alcohol 2020 Feb 28;85:153-164. doi: 10.1016/j.alcohol.2020.01.005. PMID: 32114257.
Khandai P, Forcelli PA, N’Gouemo P (2020). Activation of small conductance calcium-activated potassium channels suppresses seizure susceptibility in the genetically epilepsy-prone rats. Neuropharmacology. 2020. Feb; 163:107865. Doi: 10.1016/j.neuropharm.2019.107865. PMID: 31783064.
Wicker E, Beck VC, Soper C, Kulick-Soper CV, Hyder SK, Campos-Rodriguez C, Khan T, N’Gouemo P, Forcelli PA (2019). Descending projections from the substantia nigra pars reticulata differentially control seizures. Proceedings of the National Academy of Science of the United States of America. 2019 Dec 16. pii: 201908176. doi: 10.1073/pnas.1908176117. PMID: 31843937.
ComCompleted List of Published Work