Mark Burke, Ph.D.
Office: Numa P. G. Adams Bldg.,
Suite: 2420, Room: 2418-B
Office Telephone: 202-806-7959
Laboratory: Numa P. G. Adams Bldg., Suite: 2219
Université de Montréal Post-doctoral Fellow (Physiology)
McGill University Doctor of Philosophy (Biology)
SUNY Plattsburgh Bachelor of Arts (Psychology)
The primary focus of my research is the neuroanatomical development process and plasticity in primates. We know that through behavioral, social, and cognitive experiments the primate brain (both human and non-human) undergoes certain changes throughout the lifespan. In my laboratory we are examining several aspects of development: 1) Normal post-natal development and aging: My colleagues in Denmark and I are investigating, through magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), normal post-natal development and aging process of the vervet monkey brain. MRI/DTI will provide us with a template of developmental changes that can then be applied in the clinical setting; 2) Fetal alcohol exposure: In collaboration with the Behavioural Science Foundation, McGill University, University of Copenhagen, and University of Montreal, we are investigating the effects of naturalistic prenatal ethanol exposure in the vervet monkey. In this model, pregnant vervets were allowed to drink the equivalent of 3-5 standard drinks four times week during the third trimester. We have found cytoarchitectonic anomalies that are consistent with behavioral and cognitive and memory impairments observed in the clinical setting; 3) Pediatric HIV infection: My colleagues at University of North Carolina and UC Davis have developed a pediatric model of HIV infection in primates using simian immunodeficiency virus (SIV), which is closely related to HIV. We know that in vertical transmission of HIV infection there is an associated neurocognitive deficit (NeuroAIDS), including manifestations in individuals that receive antiretroviral therapy. Non-human primates are an invaluable translational model for our understanding of the pathogenesis of AIDS given a) their similar physiology and, b) they can be infected with SIV. The objectives of this project are to characterize the neuro-pathophysiology of SIV infection including its effects on the fronto-limbic system, hippocampus, neurogenesis, blood brain barrier and neurodegenerative mechanisms.
Selected Peer-reviewed Articles
- K. Curtis, M. Rollins, H. Carryl, K.A. Van Rompay, K. Abel, M.W. Burke (2014) Reduction of Pyramidal and Immature Hippocampal Neurons in Pediatric SIV Infection. NeuroReport accepted.
- Burke, MW, Kuppers, R, Ptito, M. (2012). Adaptive Neuroplastic Responses in Early and Late Hemispherectomized Monkeys. Neural Plasticity Special Issue “Sensory Deprivation and Brain Plasticity” 2012:852423. doi: 10.1155/2012/852423.
- Bouskila J, Burke MW, Zabouri N, Casanova C, Ptito M, Bouchard JF. (2012). Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys. Neuroscience. 202, 117. Cover Illustration
- Papia M, Burke MW*, Zangenehpour S, Palmour, R, Ervin, F, Ptito, M. (2010). Reduced neuronal size in the magnocellular layers of the lateral geniculate nucleus following fetal alcohol exposure in non-human primates. Experimental Brain Research. 205(2), 263-271. *Co-first author
- Burke MW, Zangenehpour S, Ptito, M. (2010). Partial recovery of hemiparesis following hemispherectomy in infant monkeys. Neuroscience Letters. 469, 243-247.
- Burke MW, Palmour R, Ervin F, Ptito M. (2009). Neuronal loss in frontal cortex of primates after prenatal alcohol exposure. NeuroReport. 20, 13-17.
Burke, MW (2014) Design-Based Stereology in the Brain Bank Setting. (Peter Mouton, editor). Neurostereology: Unbiased Stereology of Neural Systems. Wiley Blackwell, Oxford.
- Kamboj, H., Curtis, K., Carryl, H., Agyemang, H., Van Rompay, K., Abel, K., Burke, M. (2014). Central Nervous System Demyelination in Pediatric SIV Infection” 21th Conference on Retroviruses and Opportunistic Infections (CROI) Boston, MA.
- Bradshaw, K., Curtis, K., Graham, S., Rollins, M., Carryl, H., Heinbockel, T., Abel, K., Burke, M. (2013). The effects of pediatric SIV infection on the integrity of the hippocampus. 20th Conference on Retroviruses and Opportunistic Infections (CROI) Atlanta, GA.
- Walker, RK, Cousins, V, Burke, MW, Haddad, G. (2012). Acute alcohol effects on cardiac pro- and anti-apoptotic pathways in the perfused adult rat heart. Society for Developmental Biology, 71, Montreal Qc.
- Burke, MW & Ptito, M. (2011). Developmental plasticity following early hemispherectomy in primates. Society for Neuroscience, 41, Washington D.C.
- Burke, M., Palmour, R., Slimani, H., Ptito, M., Ervin, F. (2011). Dose-related reduction in neuronal and doublecortin positive cell number in the hippocampus following prenatal ethanol exposure in the vervet monkey. Society for Neuroscience, 41, Washington D.C.
- Burke, M., Palmour, R., Slimani, H., Ptito, M., Ervin, F. (2011). Dose-related reduction in neuronal and doublecortin positive cell number in the hippocampus following prenatal ethanol exposure in the vervet monkey. National Hispanic Science Network, Miami, Fl.
- Bouskila, J., Burke, M., Zangenehpour, S., Bouchard, JF., Ptito, M. (2010). Expression and localization of the cannabinoid receptor CB1 (CB1R) and fatty acid amide hydrolase (FAAH) in the retina of the vervet monkey (Chlorocebus sabeus). Society for Neuroscience, 40, San Diego.
- Burke, M., Palmour, R., Ptito, M., Zanenehpour, S., Ervin, F. (2010). Dose-related reduction in neuronal number in the hippocampus following prenatal ethanol exposure in the vervet monkey. Research Society on Alcoholism, 33, San Antonio, Texas.
- Burke, M., Ptito, M., Ervin, F, Palmour, R. (2010). Effects of fluoxetine on adult neurogenesis in fetal-ethanol exposed and sucrose-control vervet monkeys. Research Society on Alcoholism, 33, San Antonio, Texas.
- Burke, M., Zangenehpour, S., Ptito, M. (2009). Partial recovery of hemiparesis following hemispherectomy in infant non-human primates. Society for Neuroscience, 39, Chicago.
- Zangenehpour, S., Burke, M., Ervin, F., Palmour, R., Zatorre, R., Ptito, M. (2009). A domain-specific deficit in intersensory integration of socially relevant stimuli following naturalistic fetal ethanol exposure in vervet monkeys. Society for Neuroscience, 39, Chicago.
- Bouskila, J., Burke, M., Zangenehpour, S., Bouchard, JF., Ptito, M. (2009). Localization of the endocannabinoid system in the retina of the St. Kitts green monkey (Chlorocebus sabeus): Peripheral vs. central vision. Society for Neuroscience, 39, Chicago.
Recent Research Support
Latham Trust Foundation Principle Investigator 2014-2015
Mechanisms of pediatric SIV neurological impairment
DC-CFAR (P30AI087714) sub-award Principle Investigator 2012-2013
Altered neurodevelopment in pediatric HIV infection
Behavioural Science Foundation Principle-Investigator Grant-in-kind
Mechanisms underlying plasticity and pruning during critical periods of adolescent neurodevelopment in the non-human primate.