Catalin M. Filipeanu
M.D., University of Medicine and Pharmacy ‘Gr. T. Popa’ Iasi, Romania, 1996
Ph.D., Rijksuniversiteit Groningen, The Netherlands, 2001
G-protein-coupled receptors, intracellular trafficking, Rab GTP-ases, molecular chaperones, signal transduction, cannabinoid receptors, adrenergic receptors, orphan receptors.
Dr. Filipeanu obtained his MD in 1996 in Romania, followed by a PhD in Molecular Pharmacology in 2001 in Netherlands. Since 2007 he started his own independent lab. Dr. Filipeanu’s research focuses on G protein-coupled receptors (GPCR), one of the largest family of the human genome with over 800 members and the target of about half of the current therapies. The primary goal of the lab is to understand the fine mechanisms involved in the intracellular traffic of GPCR, with the idea to prevent the synthesis and degradation of the receptors triggering pathologic processes and do the reverse with the receptors with ‘healing’ properties. To this end, Dr. Filipeanu’s group aims to find new specific intracellular proteins, generically named ‘molecular chaperones’ which interact with particular GPCR and changes the subcellular traffic of these receptors. Pursuing this approach, the lab identified several such molecular chaperones interacting with α2C-adrenergic receptor. Aberrant subcellular localization of this receptor triggers Raynaud Phenomenon, a disease affecting about 5-10% of the population and characterized by exaggerated response to cold. Pharmacological and genetic targeting of these molecular chaperones may represent a promising novel treatment of this disease. In a different project, the lab searches for proteins interacting with CB1 and CB2 cannabinoid receptors, the main biological effectors of marijuana. Considering the worldwide controversy in the use and legalization of this drug, discovery of molecular chaperones stimulating its beneficial effects on pain prevention, antiinflammation and appetite, will offer new directions in the field. A more recent research direction of Dr. Filipeanu’s lab is to understand the effects of typical and new estrogen receptors on the neuronal function, particularly on neuritogenesis.
Selected Refereed Publications
- Filipeanu, C.M., de Vries, R., Danser, A.H., Kapusta, D.R. Modulation of α(2C) adrenergic receptor temperature-sensitive trafficking by HSP90. Biochim Biophys Acta. 2011 Feb;1813(2):346-57.
- Filipeanu, C.M., Guidry, J.J., Leonard, S.T., Winsauer, P.J. Δ9-THC increases endogenous AHA1 expression in rat cerebellum and may modulate CB1 receptor function during chronic use. J Neurochem. 2011 Sep;118(6):1101-12.
- Winsauer, P.J., Filipeanu, C.M., Bailey, E.M., Hulst, J.L., Sutton, J.L. Ovarian hormones and chronic administration during adolescence modify the discriminative stimulus effects of delta-9-tetrahydrocannabinol (Δ⁹-THC) in adult female rats. Pharmacol Biochem Behav. 2012 Sep;102(3):442-9
- Winsauer, P.J., Daniel, J.M., Filipeanu, C.M., Leonard, S.T., Hulst, J.L., Rodgers, S.P., Lassen-Greene, C.L., and Sutton, J.L. Long-term behavioral and pharmacodynamic effects of delta-9-tetrahydrocannabinol in female rats depend on ovarian hormone status. Addict Biol. 2011 Jan;16(1):64-81.
- Dong, C., Filipeanu, C.M., Duvernay, M.T., and Wu, G. Regulation of G protein-coupled receptor export trafficking. Biochim Biophys Acta. 2007 Apr;1768(4):853-70.