Advanced Problems in Pharmacology

Course Materials

Advanced Problems in Pharmacology (4 credit hours)

3 hours/week / 1 hour reading period/week



  • Thursday 1:00 pm - 4:00 pm, Pharmacology Conference Room
  • Tuesday 9/16 1:00- 4:00 pm, Pharmacology Conference Room


  • Thursday 2:00 p.m. - 5:00 p.m., TBA


Midterm    40% (written)
Final    40% (written)
Class participation    20%


Course Coordinator: Dr. Yousef Tizabi

Objectives: This course is designed to present state-of-the-art and advanced pharmacological concepts in areas critical to the functioning of a modern research pharmacologist. The laboratory components will illustrate concepts introduced during the seminar/discussions.

Format: Interactive graduate seminar. Students will be provided with a select bibliography at least 7 days prior to each session. Each student is expected to throughly read each citation and be prepared for interactive classroom participation.

9/11    Introduction to Course - Taylor 
        General Principles 
        Absorption - Bowen
9/16    General Principles (TUESDAY) 
        Metabolism- Cohen 
        Protein Binding I -John Holladay ( 3PM)
9/18    General Principles 
        Drug Elimination- Ferguson 
        Protein Binding II- John Holladay (3PM)
9/25    Dose Response in Pharmacology
        Graphics Methods in Pharmacology Research
10/2    Physical Chemistry of Pharmacology
        Computational Biology Laboratory- Southerland

10/9    Quantitative Structure-Activity-Relationships (SAR)- Hanig 
        Drug Receptor Interactions- Akinshola
10/16    Molecular Pharmacology - Vocabulary and Basic Principles- Wang
10/23    MidTerm Exam (Written)
10/30    Signal Transduction Mechanisms (G protein, IP3, etc.)- Copeland 
        Pharmacology of Drug receptors 
        1. G Protein Linked Receptors- Copeland 
        2. Ion Channel Receptors- Tizabi
        11/6    Pharmacology of Drug receptors 
        3. Voltage Activated Channel Receptors including Ca Channel Receptors- Gatti 
        4. Ligand Gated Ion Channel Receptors- Classical and others-Akinshola
        11/13    Pharmacology of Drug receptors 
        5. Excitatory and Inhibitory Channel Receptors- Wang 
        6. Neuropeptides- Massari
11/20    Quantitative methods in drug research- Laboratory-Massari
12/4    Apotosis and Cell Death - Copeland 
        Nitric Oxide - Gatti 
        Pharmacogenetics - Tizabi/Taylor
12/11    Final Exam (Written)

Suggested General Reading Resources ( available from departmental library):

  1. Alexander, S.P.H. & Peters, J.A. 1997 Receptor & Ion Channel Nomenclature Supplement: Trends in Pharmacological Sciences, Eighth Edition,1997.
  2. Foreman, John C. & Johansen, Torben. Textbook of Receptor Pharmacology, CRC Press, 1996.
  3. Kenakin, Terry. Molecular Pharmacology, Blackwell Science, Inc., 1997.
  4. Lauffenburger, Douglas A. & Linderman, Jennifer, J. Receptors: Models for Binding, Trafficking, and Signaling, Oxford University Press, 1993.
  5. Limbird, Lee E. Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition, Kluwer Academic Publishers, 1996.
  6. Pratt, William B., Taylor, Palmer. Principles of Drug Action: The Basis of Pharmacology, Third Edition, Churchill Livingstone, 1990.
  7. Shargel, Leon & Yu, Andrew B.C. Applied Biopharmaceutics and Pharmacokinetics, Third Edition, Appleton & Lange, 1993.
  8. Tallarida, R.J., Raffa, R.B., McGonigle, P. Principles in General Pharmacology, Springer-Verlag, 1988.